CZC-54252 hydrochloride

CAS No. 1784253-05-9

CZC-54252 hydrochloride( —— )

Catalog No. M28212 CAS No. 1784253-05-9

CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 50 Get Quote
5MG 82 Get Quote
10MG 129 Get Quote
25MG 251 Get Quote
50MG 447 Get Quote
100MG 655 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    CZC-54252 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2.
  • Description
    CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.(In Vitro):CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    LRRK2
  • Recptor
    PBP2|β-Lactamase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1784253-05-9
  • Formula Weight
    541.45
  • Molecular Formula
    C22H26Cl2N6O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (61.56 mM)
  • SMILES
    Cl.O=S(=O)(NC=1C=CC=CC1NC2=NC(=NC=C2Cl)NC3=CC=C(C=C3OC)N4CCOCC4)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Moya B, et al. WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones. Antimicrob Agents Chemother. 2017 May 24;61(6):e02529-16.
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